Pablo Sobrado
Professor
- Department of Biochemistry
- College of Agriculture and Life Sciences
Synopsis:
Dr. Sobrado focuses on determining the chemical mechanism, 3-D structure, and the identification of inhibitors of enzymes important for pathogenesis in Aspergillus fumigatus, Trypanosoma cruzi, and Mycobacterium tuberculosis, which cause Chagas Disease, tuberculosis and fungal infections.
Description:
Dr. Sobrado’s laboratory conducts research on the mechanism and regulation of enzyme action, structure-function of enzymes, and identification of novel kinase substrates. Projects related to infectious disease include:
- Biosynthesis of the siderophores produced by the human pathogens Mycobacterium tuberculosis, Aspergillus fumigatus, and Yersinia pestis;
- Understanding Galactofuranose (Galf) an important component of the cell surface of several pathogenic bacteria, protozoan, fungi, and mycobacterium that is not present in humans, making its biosynthetic pathway a target for new antibiotics; and
- Antibiotic biosynthesis and resistance in bacteria and fungi
- Mechanism of insecticide resistance
- High-throughput assays development and drug screening