The Discovery and Physiological Importance of Hydrogen Sulfide

Rui Wang


Dr. Rui Wang; Laurentian University, Sudbury, Ontario, Canada    

February 16 at 12:20pm in the Fralin Auditorium, Fralin Hall 102

Hosted by Dr. Dr. J. Matson


With its repulsive odor, H2S appears to be nothing but a noxious “rotten-egg” gas. Quite contrary to this conventional notion, our bodies in fact produce H2S and we are what we smell. In this talk, I will highlight some most promising and intriguing discoveries in H2S biology and medicine, including the endogenous production of H2S in the vascular system, catalized by catalysed by cystathionine gamma-lyase (CSE).  I will also address on the roles of H2S in the regulation of blood pressure and endothelium-dependent vasorelaxation, differential regulation of cell proliferation, ion channel functions, and mitochondrial bioenergetics. Collectively, the ability of the CSE/H2S pathway to regulate the cardiovascular functions suggests that that the smelly hydrogen sulfide gas is so critical to our health that we cannot live without it. (Supported by research grants from Natural Science and Engineering Research Council of Canada and the Institutes of Health Research of Canada)

Wang, PNAS, 2008, H2S as a Physiologic Vasorelaxant.pdf H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine g-Lyase
Wang, Antiox _ Redox Signaling, 2010, H2S - The 3rd Gasotransmitter in Biology and Medicine.pdf Hydrogen Sulfide: The Third Gasotransmitter in Biology and Medicine
Wang Flyer