Chronotherapy: Circadian physiology applied to glioblastoma

Paul Turner


Dr. Erik Herzog

November 8 at 12:20pm in the Fralin Auditorium, 102 Fralin Hall

Hosted by Dr. C. Finkielstein


Erik Herzog is a Professor of Biology at Washington University. His laboratory has contributed to our understanding of which cells are circadian, how circadian cells synchronize to each other and to the light-dark cycle, and how they regulate rhythms in physiology and behavior. He currently serves as the President of the Society for Research on Biological Rhythms and Director of BP-ENDURE: St. Louis Neuroscience Pipeline.

Circadian rhythms in gene expression and metabolism regulate daily rhythms in physiology and behavior across all phyla.  This talk will examine the role of different molecules, cells and circuits in the generation of daily rhythms in mammals. I will focus on daily rhythms in astrocytes and astrocytomas in the brain, how sensitivity to drugs such as chemotherapeutics for glioblastoma varies with time of day and why this is relevant to treating brain cancer.

Tso 2017 Current Bio_Astro Clocks.pdf Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior
Slat JBR 2017.pdf Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma
Herzog Flyer

This seminar will be livestreamed on the Fralin YouTube channel, but will not be recorded.