Shihoko Kojima

Synopsis

Dr. Kojima studies circadian rhythms using molecular/cellular biology, bioinformatics, and mathematical modeling, specifically focusing on rhythmic gene expression and transcription-independent gene regulatory mechanisms.

Description

The Kojima Lab is interested in understanding how rhythmic gene expression can be achieved. In mammals, approximately 50% of all mRNAs are rhythmically expressed in at least one tissue. These genes are believed to ultimately drive a wide range of rhythmic biological processes in order to maintain daily cycles. But how is this achieved? What determines the correct period, phase, and amplitude of gene expression? Why is the same gene rhythmic in one tissue but not in the other? What if they stopped cycling?

The existence of circadian clocks has been known for centuries, but their influence on health and society has only come to light in recent years. Because modern human lifestyles include many stimuli that disrupt circadian rhythms such as jet lag, bright light at night, and night shift work, understanding how the core clock regulates downstream physiology via rhythmic gene expression is important to address health concerns associated with circadian disruption.