- Biological Sciences
Dr. Capelluto’s current research centers on the molecular structure and biochemical functions of signaling transduction systems involved in membrane trafficking and cell signaling.
Our research goal is to understand how protein domains transduce signals from biological membranes. Our laboratory employs biophysical approaches including high field nuclear magnetic resonance spectroscopy, isothermal calorimetry, circular dichroism, computer modeling, liposome-binding assays, fluorescence spectroscopy and surface plasmon resonance spectroscopy. With these tools, we can determine protein:lipid interfaces, ligand binding pockets and membrane insertion of protein domains from the molecular to the atomic resolution. We validate our functional and structural approaches by using normal and disease-associated cell lines. With these tools we can establish how protein-ligand interactions control the function of proteins by modulating their subcellular localization.